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Evolution and Development of the Lungs |
Understanding the genetic and molecular basis for branching morphogenesis of epithelial tubes is important. Epithelial tubes are present in many important organs, such as kidney, glands, vasculature, as well as the airways of the vertebrate lung. Studies from animals as distantly related as insects and vertebrates are revealing key signaling networks that form structures. These data suggest many of the pathways are evolutionarily conserved. We are interested parcing out the details of lung bud formation in crocodilians. We aim to use this information throw into sharp relief similarities and differences in developmental patterns of the avian and crocodilian lung.
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Fertilized chicken eggs were incubated under different atmospheric conditions: first cypercapnia at 3% Co2, and then hypercapnea at 1% CO2. The control was incubated under normoxia. During the incubation period individuals were pulled at specific states (ED5, ED8 , and ED10) and their development was compared to individuals from the control group. No signifcant difference was found in timing or size of structures under different atmospheric conditions. However, there was a significant increase in chick mortality and deformity in the 3% CO2 trial.(AW Bell) | ||||||||
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Chick lungs ED8 from 1% CO2 |
Chick lungs ED8 from control group | |||||||
Chick lungs ED10 from 1% Co2 |
Chick lungs ED10 from control group |
Chick embryo ED10(control) |
Deformed chick embryo ED10 from 3% CO2 |
Undeveloped chick embryo ED10 from 3% CO2 |
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